Arrancó el Draft 2022 de la NFL y la primera selección resultó sorpresiva con la 1a selección de Jaguares de Jacksonville para Travon Walker, lo cual vino a alterar todos los pronósticos.
| PRIMERA RONDA | |||
| Equipo | Jugador | Posición | Universidad |
| Jacksonville Jaguars | Travon Walker | EDGE | Georgia |
| Detroit Lions | Aidan Hutchinson | EDGE | Michigan |
| Houston Texans | Derek Stingley Jr | CB | LSU |
| New York Jets | Sauce Gardner | CB | Cincinnati |
| New York Giants | Kayvon Thibodeaux | DE | Oregon |
| Carolina Panthers | Ikem Ekwonu | OT | N.C. State |
| New York Giants | Evan Neal | OT | Alabama |
| Atlanta Falcons | Drake London | WR | USC |
| Seattle Seahawks | Charles Cross | OT | Mississippi |
| New York Jets | Garrett Wilson | WR | Ohio St |
| New Orleans Saints | Chris Olave | WR | Ohio St |
| Detroit Lions | Jameson Williams | WR | Alabama |
| Philadelphia Eagles | Jordan Davis | DT | Georgia |
| Baltimore Ravens | Kyle Hamilton | S | Notre Dame |
| Houston Texans | Kenyon Green | OG | Texas A&M |
| Washington Commanders | Jahan Dotson | WR | Penn St |
| Los Ángeles Chargers | Zion Johnson | OG | Boston Coll. |
| Tennessee Titans | Treylon Burks | WR | Arkansas |
| New Orleans Saints | Trevor Penning | OT | Northern Iowa |
| Pittsburgh Steelers | Kenny Pickett | QB | Pittsburgh |
| Kansas City Chiefs | Trent McDuffie | CB | Washington |
| Green Bay Packers | Quay Walker | LB | Georgia |
| Buffalo Bills | Kaiir Elam | CB | Florida |
| Dallas Cowboys | Tyler Smith | OT | Tulsa |
| Baltimore Ravens | Tyler Linderbaum | C | Iowa |
| New York Jets | Jermaine Johnson II | DE | Florida St |
| Jacksonville Jaguars | Devin Lloyd | LB | Utah |
| Green Bay Packers | Devonte Wyatt | DT | Georgia |
| New England Patriots | Cole Strange | OG | Chattanooga |
| Kansas City Chiefs | George Karlaftis | EDGE | Purdue |
| Cincinnati Bengals | Dax Hill | S | Michigan |
| Minnesota Vikings | Lewis Cine | S | Georgia |
